Adalat

Category:

Description

Adalat is the only hypotensive drug, whose active substance is Nifedipine. Its action is aimed at suppression of production of calcium compounds in the cells (with a spasmolytic effect).
Nifedipine reduce the tone of smooth muscles of coronary arteries, thereby preventing angiospasm, increasing the bloodstream in the post-stenonic vessels and improving the oxygen delivery to the myocardium, and reduce the oxygen demand of myocardium by reducing the peripheral vascular resistance (post-loading), and in case of prolonged use can prevent the new atherosclerotic damages in the coronary arteries.

Indications for the use of Adalat

Angina (tension, stable angina without angiospasm, stable vasospastic angina, unstable vasospastic angina in case of inefficiency of beta-blockers and nitrates); arterial hypertension (including vasorenal), relief of a hypertonic crisis; Raynaud’s disease; coronary artery spasm (during the diagnostic or therapeutic interventions – Percutaneous transluminal coronary angioplasty, recanalization of vessels or aortic bypass); differential diagnosis between the functional and organic coronary artery stenosis; hypertenstion of “small” circulatory system.

Special indications

You can chew the pill of Adalat to accelerate the effect. If you’re having chest pains during the treatment, the drug should be withdrawn. Driving a car isn’t recommended at the beginning of the treatment. Alcohol consumption leads to the excessive reduction of pressure. You shouldn’t combine Adalat with nitrates. However, the combination with beta-blockers is used frequently and successfully, but requires the adequate selection of dosage.

Way of use and dosage

The dosage and duration of treatment are established individually depending on the seriousness of the disease and the sensitivity to the drug. Recommended initial dosage is 30 mg a day. Maximum daily dosage is 120 mg.
Older patients receiving the combined (anti-angina or anti-hypertensive) therapy should reduce the dosage.
The patients with liver dysfunctions and serious cerebrovascular diseases should reduce the dosage.

Contraindications:

Hypersensitivity, severe arterial hypotension (systolic blood pressure is lower than 90 mm Hg), pregnancy and lactation period.
Take the drug with caution if have the following diseases:
Expressed aortic valve or mitral valve stenosis, hypertrophic obstructive cardiomyopathy, expressed bradycardia or tachycardia, sick sinus syndrome, chronic heart failure, minor or moderate arterial hypotension, serious impairments of cerebral circulation, myocardial infarction with left ventricle failure, bowel obstruction (in the form of slow excretion), liver and kidney failure (especially for the patients on haemodialysis care, as this causes a high risk of excessive and unpredictable reduction of blood pressure), old age, children under 18 years old (effectiveness and safety of use are unknown).

Side effects

Cardiovascular system: some patients noted an increased heart rate, reduced systolic blood pressure and vertigo at the initial stage of treatment with Adalat. More rare side effects are: crural swelling, orthostatic collapse and chest pain.
Digestive tract: some patients noted dyspepsia and elevated liver transaminases levels in the laboratory test.
Individual patients associated the use of Adalat with an increased dieresis. The patients with kidney dysfunction rarely noted the deterioration in the functional state of urinary system.
The allergic reactions, caused by the use of Adalat, include: allergic rash with itching and burning. Individual patients noted short-term reactions in the form of subjective sense of heat in the upper part of the body, myalgia, diplopia. The long-term use of the drug can cause gingival hyperplasis and gynecomastia in men.