Anacin is a drug that has analgesic, antipyretic and anti-inflammatory action.
Indications for use
Anacin is used for pain in case of the following diseases/conditions: Migraines; Injuries; Dysmenorrhea; Neuralgia; Toothache and headache; Myalgia; Arthralgia.
Also the drug is used in case of infectious and inflammatory diseases that are accompanied by febrile conditions.
Severe hepatic and renal failure; Hypersensitivity to the drug; Children under 12 years of age. It should be used with caution in cases of: Viral hepatitis; Chronic alcoholism; Benign hyperbilirubinemia; Pregnancy; Lactation.
Method of application and dosage
Anacin is taken at the dose of 500 mg 3-4 times per day. It is not recommended to exceed the maximum daily dose of 4 g and to continue taking the drug longer than 5-7 days.
The use of Anacin may cause the following side effects: Dyspepsia gastrointestinal; Thrombocytopenia, agranulocytosis, leukopenia, neutropenia, pancytopenia; Allergic reactions manifested as pruritus, rash and urticaria.
If it is necessary to use Anacin during pregnancy, in case of liver dysfunction and kidney failure, Gilbert’s syndrome, as well as to old people, it is recommended to reduce the daily dose and reduce the duration of the drug. Use caution while taking the drug with other anti-inflammatory and antipyretic drugs, as they may contain paracetamol, and oral corticosteroids, anticoagulants and acetylsalicylic acid.
Symptoms: in the first 24 hours — pallor, nausea, vomiting and pain in the abdominal area; after 12-48 h — damage to the kidneys and liver with development of hepatic failure (encephalopathy, coma, death), cardiac arrhythmias and pancreatitis. Liver damage is possible when taking 10 g or more (by adults).
Treatment: the appointment of methionine orally or the prescription of N-acetylcysteine intravenously.
Interaction with other drugs
It increases the effect of indirect anticoagulants (coumarin derivatives) and the probability of liver damage by hepatotoxic drugs. Metoclopramide increases, and cholestyramine reduces the rate of absorption. Barbiturates reduce antipyretic activity.
Precautions when taking
The risk of overdose is increased to patients with alcoholic liver disease of non-cirrhotic character.