Aspirin is one of the most well-known non-steroidal anti-inflammatory drugs used in modern medical practice.
Release form and composition
The active substance is acetylsalicylic acid serving as the basis for many drugs, the so-called “salicylates”. Pharmacies medicine can be purchased in tablets of 100 or 500 mg of the active ingredient, as well as in the form of effervescent tablets in which the content of active substance is equal to 350 mg.
According to the fact that this tool is a NSAID (non-steroidal anti-inflammatory drug), it has anti-inflammatory, antipyretic and analgesic effect. The effectiveness of Aspirin is due to the influence of acetylsalicylic acid on COX-2 (cyclooxygenase) that is responsible for the production of prostaglandins, and thus for the development of inflammation, pain and fever. This drug has antiplatelet effects, and thus, it thins the blood and inhibits platelet aggregation. So, Aspirin reduces mortality in case of unstable angina and myocardial infarction.
Indications for use
The drug is advisable to appoint in such cases:
- pain in rheumatic diseases;
- severe migraine attacks;
- pain syndromes of different genesis (tooth or a headache, both strong and mild);
- fever occurs in inflammatory diseases;
- the prevention of thrombosis and embolism;
- prevention of myocardial infarction (in individuals with angina pectoris);
- secondary prevention of heart attack;
- coronary disturbances of the circulation of the brain.
How to take Aspirin
Usually a single dose medication should be taken 3x a day, and the interval between doses tablets should range between 4-8 hours. In individuals with disorders of the liver or kidneys, the interval should be 8 hours or significantly reduced dose.
In case of fever, rheumatic, toothache, or head pain, the single dose for children older than five years should be 0.25–0.75 g of Aspirin (maximum daily dose – 1.5 g). Single dose for adults should not be higher than 1 g, and daily – no more than 3 grams. The same dosage is prescribed in the case of migraine attacks. Cerebrovascular disease and prevention of heart attack in the case of unstable angina imply a dose of 0.1 g 3 p/day.
Pills should be taken before eating, and they are swallowed as a whole or dissolved in water. It is strictly prohibited to take the drug without the appointment of a specialist more than 3 days.
The instruction describes such cases when doctors don’t prescribe Aspirin:
- ulcerative lesions of the stomach;
- arterial hypertension;
- bronchial asthma that was triggered by NSAIDs, or salicylates;
- renal or liver failure;
- hemorrhagic diathesis;
- enlargement of the thyroid gland;
- severe heart failure.
In addition, Aspirin is not prescribed to women during the breastfeeding period in the first trimester of pregnancy or in case of hypersensitivity to components of drug. This drug is prescribed with caution to children up to 15 years.
Be aware that Aspirin can cause such uncomfortable symptoms as epigastric pain, nausea or vomiting, bronchospasm (in asthmatics), and also allergic reactions, for example skin rash.