Description
Indications
- Essential hypertension
- Kidney lesion in hypertension and achrestic diabetes mellitus(consisting of complex therapy)
Posology and method of administration
The usual recommended and supporting dose of Avalide is 150 mg once a day. The drug can be taken regardless of meals. The pills should be swallowed whole with water. If it is necessary, the dose can be increased to 300 mg 1 time per day or prescribe combine antihypertensive therapy.
Patients with non-insulin dependent diabetes mellitus and arterial hypertension drug is started to take at a dose of 150 mg once a day and then increase the dose to 300 mg once a day, which is preferred maintenance dose in renal disease. Persons older than 75 years should start therapy with 75 mg.
- Violation of renal function.
- Patients with impaired renal function shouldn’t change doses.
- Patients on hemodialysis should start therapy with 75 mg.
- Inadequate intra-vascular blood volume.
- Before you start the application of Avalide you must bridge deficit of liquid and / or sodium.
- Disturbances of hepatic function.
- Patients with mild or moderate hepatic function violation correction shouldn’t correct the dose.
Side effects
- Hypersensitivity reactions, such as skin sprinkle, urticaria, angioedema
- Hyperkalemia
- Headache, dizziness
- Noise in ears
- Nausea and / or vomiting
- Dysgeusia
- Weakness
- A significant increase of creatine kinase levels
- Orthostatic dizziness
- Orthostatic hypotension
- Hepatitis, change of hepatic function
- Arthralgia, myalgia (in some cases in combination of increased levels of creatine kinase (CK)), muscle cramps
- Renal function violation including cases of acute renal deficiency in patients with an increased risk
- Leukocyte vasculitis
Infrequently
- Heart hurry
- Hot flushes
- Cough
- Diarrhea, dyspepsia, heartburn
- Sexual dysfunction
- Chest pain
- Treatment should be discontinued with the development of severe adverse effects
Contraindications
- Hypersensitivity to the active substance or helpful components of the drug
- Pregnancy and lactation
- Child and adolescence to 18 years
- Primary hyperaldosteronism
