Azulfidine is anti-inflammatory drug that is used for diseases of the digestive tract. The name of the main component of the medication is the same as its trade name. Treatment with Azulfidine leads to the accumulation of active substances in the intestine (in the tissues). Disentangling, it has anti-inflammatory effect and inhibits infectious processes. Splitting of Sulfasalazine into components occurs under the action of microflora.
Indications for use
- Crohn’s Disease;
- Ulcerative colitis – at any stage;
- Rheumatoid arthritis, including juvenile;
Azulfidine is released in the form of pills. In the first three days of therapy you may increase the dosage according to this standard procedure:
- First day – one tablet four times;
- Second day – two tablets four times;
- Third and forth days – three or four pills four times;
The instruction of the drug reports that when the symptoms subside, the patient is transferred to a maintenance dose of one tablet three or four times a day. The duration of course can be several months. You need take Azulfidine before meals.
This scheme is not prescribed to children. They are prescribed half a tablet or a whole tablet from three to six times a day.
- Severe lesions of the liver and kidneys;
- The deficit of glucose-6- phosphate dehydrogenase;
- Diseases of the blood;
- Lactation into the third trimester of pregnancy;
- The treatment of children under five years of age;
- It should be used with caution in case of:
Pregnancy, only in the first two trimesters (reduced doses on strict conditions);
Side effects and overdose
According to reviews, the drug can cause disorders of the various body systems:
Genito-urinary system – haematuria, proteinuria, nephrotic syndrome, crystalluria; Nervous system – peripheral neuropathy, headache, aseptic meningitis, hallucinations, dizziness, sleep disturbance, seizures, depression, ataxia; Respiratory system – infiltrates in the lung tissue, shortness of breath, interstitial fibrosing alveolitis, pneumonitis, cough; Digestive system – pancreatitis, vomiting, drug-induced hepatitis, nausea, abdominal pain, diarrhea, stomatitis, decreased appetite.
According to reviews, the violations of blood during therapy are often manifested in the form of leukopenia, macrocytosis, megaloblastic anemia, neutropenia, aplastic, hemolytic anemia, agranulocytosis, methemohlobinemia, hypoprothrombinemia, thrombocytopenia.
The most frequent allergic reactions during the treatment with Azulfidine are:
Generalized skin rash; Erythema; Urticaria; Exfoliative dermatitis; pruritus; anaphylaxis; Malignant exudative erythema; Photosensitivity; Toxic epidermal necrolysis (Lyell’s syndrome); Lymphadenopathy; Fever; Periorbital edema; Serum sickness; periarteritis nodosa; Eosinophilia.
In addition, the reception of Azulfidine may lead to development of parotitis, tinnitus, hyperthermia, and hyperbilirubinemia.
The reception of large doses of Azulfidine, as a rule, leads to overdose, which is expressed in the form of digestive disorders (vomiting, nausea, abdominal pain) and dizziness. The use of Azulfidine in very high doses often causes crystalluria, anuria, seizures and hematuria.
Overdose may cause:
- Abdominal pain, nausea, vomiting, dizziness.
- Treatment assignment
- Gastric lavage, symptomatic therapy and forced diuresis.