Drug Description

Benemid or Probenecid is a drug used to increase the excretion of uric acid in urine, as its high concentration in blood may cause gout and diabetes. This medicine represents an alternative to the drug caronamide.


Benemid is mainly used for the treatment of gout, arthritis and hyperuricemia (increased level of uric acid in blood). Sometimes Benemid is combined with antibiotics to increase the concentration level of the drug. It is also used as a masking agent (used to hide or prevent detection of a banned substance or illegal drug).


Benemid must be taken by mouth with water. People taking this drug for the treatment of gout must drink enough liquid to prevent kidney stones. You should take the drug twice a day during the meal to avoid indigestion. Consult the doctor before starting the treatment, as he/she may tell you how to decrease the acidity content in urine by taking this drug.
You should begin the treatment with a small dosage of Benemid, and then gradually increase the dosage depending on the content of uric acid and severity of gout symptoms. This drug is contraindicated to the patients with serious gout attack.

Essential information

You should be especially careful while taking zidovudine, penicillin, ganciclovir, lorazepam and quinolone together with Benemid. Inform the doctor if you’re taking these drugs before starting the treatment with Benemid.
Tell your physician if you’re allergic to Probenicid or any other drug components.
Inform your doctor if you suffer from the following diseases: anemia, kidney or renal dysfunction, kidney stones, myelosuppression, any blood disorders or cancer (including in history).
Sometimes, Benemid can cause vertigo. It is desirable to avoid driving or operate any hazardous machinery during the treatment with this drug. Don’t drink alcohol, as it may enhance the risk of adverse effects.
If you’re going to have any surgery (including dental) inform your doctor that you’re taking this drug.
The drug withdrawal must be gradual in older patients suffering from kidney dysfunction. Adverse effects are also more common in older people.
Pregnant and lactating women must inform the doctor about their medical condition and take the drug only after the doctor’s approval (and only in cases of absolute necessity).

Adverse effects

The use of this drug may cause the following adverse effects: urinary frequency, vomiting, head pain, sickness and lack of appetite. However, all this may occur only in the initial stage of treatment. If the adverse effects persist, the patient must stop the treatment and consult the doctor.