Bupropion

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Description

Indications for use of Bupropion

Bupropion is indicated for the treatment of depression.

The use of bupropion to treat obesity

Bupropion, as a medication for weight loss in patients with addiction to smoking, is used as a drug that improves the effect of lifestyle changes (low-calorie diet and exercises) and is assigned to patients with a body mass index (BMI = body weight in kg / (height in m) 2)

  • for patients without concomitant diseases – a BMI of at least 30 kg / m2
  • for patients with a BMI of at least 27 kg / m2 with associated diseases.

When you are treating the obesity by Bupropion (400 mg daily) for the period of 6 to 12 months the average weight loss is 4.4 kg , which is significantly higher than the placebo group. It is virtually identical to the weight loss during therapy with drugs such as orlistat and sibutramine, amfepramone.

Contraindications to the use of Bupropion

Bupropion is contraindicated in case of:

  • hypersensitivity to bupropion
  • convulsive disorders
  • simultaneous use of multiple medications containing bupropion (to avoid overdose)
  • abrupt cancellation of reception of alcohol or sedatives
  • reception at the same time with monoamine oxidase inhibitors (MAOIs) such as furazolidone, rasagiline (Azileсt), selegiline (Yumeks), isocarboxazid, phenelzine, procarbazine, traniltsipramin and other or if MAO inhibitors were taken during the previous two weeks.

Side effects of bupropion

Bupropion therapy may cause:

  • very often: dry mouth, dyspeptic disorders, including nausea and vomiting
  • often: abdominal pain, constipation, visual disturbances, tinnitus, high blood pressure, rash, itching, sweating, fever, chest pain, asthenia
  • sometimes: tachycardia
  • very rare: palpitations, vasodilatation, hypotension, hepatitis, erythema multiforme. Steven-Johnson syndrome, limbs twitching, increased urination or delay of last one.

The use of bupropion by pregnant, breast-feeding and children
Bupropion and its metabolites permeate in breast milk. Therefore, it is not recommended to breastfeeding mothers. If the bupropion therapy is necessary for the mother, breast-feeding should be discontinued.
Bupropion has a category of risk to the fetus during using the drug by pregnant according FDA «C» (studies in animals have revealed adverse effects of drugs on the fetus, but adequate studies in pregnant women has not been, however, the potential benefits associated with the use of the drug in pregnant women may justify its use, despite the risk).
Bupropion is not recommended for children to 18 years.