Cardizem belongs to the benzodiazepine derivatives and calcium channel blockers. The drug can also reduce the intracellular content of calcium ions.
Cardizem can extend coronary and peripheral arterioles and arteries, reduce the general peripheral vascular resistance, improve the brain, coronary and kidney blood flow and reduce the frequency of heartbeat.
The drug is used to achieve the following impact
- Anti-arrhythmic, caused by the suppression of calcium transportation via the heart tissues,
antianginal, explained by the dilation of peripheral vessels and reduction of post-load (systemic blood pressure).
- It reduces the tension in myocardial wall and its oxygen demand. Cardizem can cause the relaxation of smooth vascular muscles in such concentrations that can’t cause inotropic negative effect.
- Antihypertensive, caused by the dilatation of vessels. The level of blood pressure reduction directly correlates to the initial level. The drug can improve diastolic relaxation of myocardium and the condition in hypertension, hypertrophic cardiomyopathy and ischemic disease.
Cardizem quickly (and fully) absorbed into the G.I. The drug achieves its maximum concentration in blood plasma in 6-15 hours.
Indications for use
- The treatment of patients with arterial hypertension.
- Treatment and prevention of strokes.
- Hypersensitivity to the active substance Diltiazem and other drug components
- Sick sinus syndrome
- Sinus bradycardia
- Sinoatrial and atrioventricular block of 2 or 3 stage (without the use of pacemaker)
- Wolff-Parkinson-White and Lown-Ganong-Levine syndrome with paroxysmal glimmer or atrial flutter (except from patients with pacemaker)
- Cardiogenic shock
- Arterial hypotension
- Acute myocardial infarction
- X-ray confirmed pulmonary hypertension
- Pregnancy and lactation
- Expressed kidney and liver dysfunction
- Expressed aortic stenosis
- Systolic left ventricular dysfunction
The drug is usually well-tolerated by the patients. However, you can face the following adverse reactions: vertigo, headache, weakness and fatigue, lower limbs edema, sleep disorders.
Possible reactions of digestive tract include: sickness, vomiting, dry mouth, flatulence, constipation and heartburn; skin reactions are rash and exanthema.
Overdose can cause the following unpleasant symptoms
- Arterial hypotension
- Tachycardia and bradycardia
- Different disorders of AV-conduction
- If you note the above-mentioned symptoms, get your stomach pumped, take activated charcoal and consult your doctor
The patients, taking this drug, must get their heart rate and blood pressure monitored and run an EKG. Such examination is necessary at the beginning of treatment to choose the dosage, or if you take the other drugs able to affect the heart work.
The drug must be withdrawn gradually (reduce the dosage day by day).
Cardizem must be used with caution by the patients with tendency to bradycardia, arterial hypotension, intra-ventricular conduction disorder, liver and kidney dysfunction.
Don’t mix the drug with alcohol.
Safety and efficiency of this drug for children has not been established.