Cleocin – is an antibiotic and semi-synthetic lincosamide. Having low concentrations of active substances, the drug has bacteriostatic action, i.e. breaks the process of reproduction of bacteria. If the dose is increased – Cleocin will kill adult forms of microorganisms. This drug is proven for a wide range of gram negative and gram positive bacteria, aerobes and anaerobes. Resistance to Clindamycin is shown by gram-negative aerobic bacteria. While treating, be aware that microorganisms that are resistant to macrolide antibiotics, e.g. erythromycin, are not sensitive to this drug. Cleocin is used to treat infections localized in the joints, bones, soft tissues, respiratory tract, abdomen, female sex organs and so on.
Depending on the type of treatment, you can use capsule, syrup, gel for topical application or vaginal cream, Cleocin injections. The instruction reports about various regimens and dosages of the substance, standardized for different groups of patients. You are forbidden to use CLEOCIN if you have intolerance to its substances, but also during pregnancy, lactation, severe liver, kidney, gut, and to children of the first month of life. However, it is sometimes possible to prescribe this antibiotic to newborns with tiny doses.
Side effects and overdose
Unwanted actions of Cleocin, are in principle, standard for all antibacterial drugs. They are dysfunction of the system of digestion, liver function, allergic reactions, fungal super-infection overgrowth. In case of development of acute intolerance reactions, the therapy with antihistamines is possible. Usually, an overdose with this drug does not require emergency measures, as it is very rapidly excreted from the body.
Symptoms: increased severity of side effects.
Treatment: symptomatic and supportive ones. It is not displayed by hemodialysis and peritoneal dialysis.
Interaction of Cleocin with other drugs
The drug is incompatible with solutions containing a complex of vitamins of group b, aminoglycosides, ampicillin, phenytoin, barbiturates, aminophylline, calcium gluconate and magnesium sulfate.
The reception of the drug leads to antagonism of Cleocin with erythromycin and chloramphenicol.
It enhances the action of competitive muscle relaxants.
The simultaneous use of the drug with opioid (narcotic) analgesics may cause the respiratory depression (up to apnea).
Simultaneous reception of Cleocin with anti-diarrheal drugs that reduce the motility of the gastrointestinal tract, increases the risk of pseudo-membranous colitis.
Aminoglycosides increase the spectrum of antimicrobial action; increase (mutually) the effect of rifampicin.