Colchicine has been traditionally used for the treatment of gout: to ease symptoms of acute gout and for the prevention of its exacerbations, especially during the first few months of treatment with allopurinol or means that promote the excretion of uric acid. In this capacity, Colchicine has no no viable alternative to the present time.
In case of acute gout, Colchicine causes an impressive reaction, most likely due to reduced expression of inflammation caused by the urate crystals. This is achieved by running several different mechanisms, including reduction in the motility of leukocytes. We must understand that among these mechanisms, there is nothing like analgesia, as there is no decrease in the concentration of serum uric acid, or increase of its excretion from the body. Moreover, Colchicine has an anti-mitotic effect.
In case of acute attack of gout, treatment with Colchicine should begin as early as possible, and the effects of actions can occur within the first 12 hours.
Method of application and dose
- In order to avoid complications you should use Colchicine only after consulting your doctor.
- Pills or capsules are swallowed as a whole, with liquid.
In case of an acute attack of gout you should at first take 1 mg of Colchicine, then 0.5-1.5 mg every 1-2 hours until relief of pain. The total dose adopted for the day, should not exceed 8 milligrams of Colchicine On the 2nd and 3rd days of treatment the daily dose is 2 mg (in two doses). On the 4th and subsequent days you are prescribed 1 mg a day (in the evening). Re-treatment of an acute attack of gout can be conducted not earlier than in 3 days.
In order to prevent acute gout attacks in the first few months of treatment with uricosuric means you should take 0.5-1.5 mg of the drug daily or every other day (in the evening) within (usually) 3 months. The same dosing regime is used for other indications.
Colchicine is contraindicated in case of:
- acute renal or liver failure;
- serious disorders of the cardiovascular system, bone marrow, gastrointestinal tract;
- purulent infections;
- old age;
- hypersensitivity to the active ingredient Colchicine.
Reception of Colchicine may cause side effects:
- CNS: depression, neuropathy, peripheral neuritis.
- Digestive system: pain in the abdomen, nausea, vomiting, diarrhea, loss of appetite, malabsorption syndrome (deficiency vitamin B12), disruption of the normal functioning of the liver.
- Hematopoietic system: neutropenia, aplastic – anemia, myelosuppression, agranulocytosis, leukopenia. Thrombocytopenia develops in the background of a long reception.
- Allergic reactions: urticaria, morbilliform rash.
Other side effects: disruption of the normal functioning of the kidneys, temporary alopecia (hair loss), azoospermia, myopathy.