One of the common drugs that prevent blood clots, is Dipyridamol. The mechanism of action of this drug is quite complicated, therefore, you won’t do without special medical and chemical terms. The instruction for use of the drug indicates that this medication dilates the coronary vessels, preventing platelet aggregation. In result the volume rate of coronary blood flow significantly increases, the myocardium is better supplied with oxygen and becomes more resistant to hypoxia. This medicine can also improve renal and cerebral blood flow.
The active component of the drug is dipyridamole, which has vasodilatory action. Dipyridamol increases the contents of adenosine and inhibits phosphodiesterase in blood plasma. Adenosine is a substance that is involved in important biochemical processes in the human body, as ADP and ATP (energy transfer), cyclic amp (signalling). Adenosine has a direct effect on coronary blood flow by dilating blood vessels. In turn, it inhibits phosphodiesterase, the concentration of adenosine in plasma. The active substance of Dipyridamol is dipyridamole that inhibits the action of phosphodiesterase. As a result, the speed and volume of blood flow increases.
The Instructions for use of the drug notes that this therapeutic agent is used for the treatment and prevention of venous and arterial thromboses, for prevention of embolism after operations on the heart, for the restoration of disturbed microcirculation of blood in complex therapy. This medication is recommended for people with vascular encephalopathy, angina, for the treatment of disorders of cerebral circulation in ischemic heart disease. Dipyridamol is often used in complicated pregnancy for the prevention of placental insufficiency. As immunomodulator and interferon inducer, the small doses this drug is used even for the treatment of SARS and influenza.
Dipyridamol was produced in the form of pills, tablets, vials for injection. The dose and course of treatment are prescribed by your doctor after a thorough examination of the patient. The tablets are usually taken 3 times a day an hour before meals. In the gastrointestinal tract the drug is quite rapidly absorbed. It should be noted that due to the numerous side effects intramuscular and intravenous administration of this medication is rarely used.
The side effects that have been observed in some cases include headache, nasal bleeding, low blood pressure, dizziness, and nausea. There may also be increased sensitivity of the gums, dark urine, pain in region of liver, dyspepsia, pruritus. If you experience any of these symptoms, you need to stop taking the drug and immediately consult a doctor.
As any vasodilator which directly affects cardiac function Dipyridamol has an extensive list of contraindications. First and foremost, they are acute myocardial infarction, hypotension, sub-aortic aortic stenosis, stenosing atherosclerosis of the coronary arteries, cardiac arrhythmia and unstable angina. It is forbidden to take this medication if you are hypersensitive to dipyridamole or you have chronic obstructive pulmonary disease (COPD), hemorrhagic diathesis, chronic liver and kidney failure. Due to the increased risk of bleeding, Dipyridamol is contraindicated in case of gastric ulcer and duodenal ulcer. It is not recommended to use this remedy to children under 12 years of age.