Drug Description

Hydrochlorothiazide is a diuretic, available only on prescription. This drug is also available in the brand version, approved by FDA (1959). It is sold in the form of pills with dosage of 12.5 mg, 25 mg, 50 mg and 100 mg and in the form of capsules with the dosage of 12.5 mg. The drug looks like white crystalline powder, almost insoluble in water, and contains several inactive components (corn starch, magnesium stearate and lactose monohydrate).


Hydrochlorothiazide is mostly used for the treatment of hypertension and liquid retention (or edema) in patients suffering from congestive heart failure, kidney dysfunction, liver cirrhosis or swelling caused by using steroids or estrogen.
Hydrochlorothiazide acts by preventing the salt and liquid absorption from the urine, which can result in diuresis. Moreover, it is used for the treatment of calcium kidney stones.


Hydrochlorothiazide pills must be taken orally once a day, irrespective of the mealtime. Patients with high blood pressure and edema require different drug dosage. We advise you to take the pills before 6pm in order to prevent frequent urination at night. It is advisable to take the drug at the same time every day to achieve the best results from the treatment. The drug dosage depends on the patient’s age, health condition and their reaction to the drug.

Adverse effects

Some patients can get serious skin allergies and Stevens – Johnson syndrome including erythroderma. Other adverse reactions include kidney dysfunction and vision impairment. Stop using the treatment and seek immediate medical assistance if you suffer from irregular heartbeat, muscle fatigue, diarrhea, lack of appetite, sickness, vomiting, stomachache or constipation.


The drug can interact with other drugs, herbal supplements or any vitamins. Therefore, you should inform your doctor about any medicines you’re currently taking.
Avoid drinking alcohol during the treatment, as it can cause dizziness. Don’t mix narcotics with Hydrochlorothiazide as narcotic drugs, as it can cause addiction and serious health problems.
If you take any miorelaxant, anti-epilepsy medications or anti-depressants, inform your doctor about it to prevent any possible adverse effects.
Tell your physician if you have kidney dysfunction, asthma or diabetes before starting the treatment with Hydrochlorothiazide.