Keflex is a semi-synthetic cephalosporin antibiotic of the first generation of wide spectrum of action, intended for oral taking.
The drug has a bactericidal effect, inhibiting the synthesis of peptidoglycan cell walls of microorganisms. It is active against gram-positive bacteria (staphylococci, producing and not producing penicillinase; streptococcus, pneumococcus, bacillus diphtheria) and gram-negative microorganisms (meningococci, gonococci, shigella, salmonella, escherichia coli). It is ineffective against sticks blue-green pus, indolgenic strains of proteus, mycobacteria tuberculosis, anaerobic microorganisms. It poorly permeates through GEB, but passes into breast milk. There is biotransformation in the liver. It is exuded mainly by kidneys, partly excreted in the bile.
FEATURES OF THE APPLICATION
The use of Keflex during pregnancy and lactation is shown only in those cases where the intended benefits to the mother outweigh the risk of possible negative effects on the fetus.
Be wary appointed to the human liver and/or kidney disease, the indications colitis in history. There is a possibility of cross-allergy between cephalosporins and penicillin antibiotics. So, the drug should be taken carefully by patients who have the allergy to penicillins.
Patients who take cephalosporins or penicillins, may positive Coombs test and false positive reaction of urine for sugar.
During the treatment you should not drink alcohol.
INDICATIONS FOR USE
Keflex is indicated for the treatment of infections caused by sensitive microorganisms: infections of the upper and lower respiratory tract, urinary tract, infections of skin and soft tissues, bones and joints, ENT infections, gynecological and postpartum infections, septicemia, gonorrhea.
Keflex side effects
To date, there are no identified cases of severe, irreversible abnormalities when taking this antibiotic. Usually adverse events disappear at the end of the course. They can be diarrheal disorders, allergic reactions, weakness, temporary changes in blood counts. There were rare cases of developed liver damage, hepatitis. However, any change of the patient’s condition should be reported to the specialist.
Hypersensitivity to cephalosporins.
INTERACTION WITH OTHER MEDICINAL PRODUCTS
Keflex may potentiate the effects of anticoagulants.
The cases of overdose were not reported.