Lisinopril is a drug which affects the vascular system and heart. The active ingredient of the drug, which is called similarly, refers to the pharmacological group of inhibitors of ACE. The same drug is Diroton. In other words, lisinopril prevents the conversion of angiotensin I to angiotensin II. The result is the falling of pressure in large arterial vessels (mainly the arteries). On the contrary, in capillaries the blood flow increases. The maximum reduction in blood pressure is observed in six hours after taking a dose. Treatment with Lisinopril improves heart health. After prolonged use of the drug, the hypertrophied myocardium returns to its normal state. In addition, this drug has the ability to reduce urinary protein excretion. This occurs thanks to the improvement of the “filter” of the tissue in the kidneys.
Lisinopril is used when
- Failure of cardiac function in the chronic form
- In the early stages of treatment of myocardial infarction – maintaining function of the left ventricle
- Diabetic kidney damage
Lisinopril is released in the form tablets with different concentration of active substance. You should begin treatment with low doses, which are then adjusted depending on efficiency. The instruction of the drug notes that patients who take diuretics, need to stop taking them in a couple of days before they start using this medicine. Otherwise, there can be too severe drop in blood pressure. Therefore, a patient should be under medical supervision for six hours after taking a dose of Lisinopril (in order, if necessary, to adjust the condition of the patient, maintaining a normal blood pressure level).
Patients with impaired renal function and old people require correction of the quantity of the drug. Because in those situations the exchange lisinopril broken. In general, there are separate standards for the use of this medicine for different indications, which are described in the annotation of Lisinopril.
The use of this medication does not depend on food intake.
Lisinopril is contraindicated in cases when
- Cases of angioedema like reactions to drugs of the group of ACE inhibitors
- Possible angioedema (hereditary)
- Other types of intolerance
- Treatment of minor patients
It should be used with caution in cases of
- Impairment of renal blood flow
- Kidney failure
- Coronary heart disease
- Disorders of blood supply of a myocardium
- Autoimmune lesions
- Some violations of water-salt balance
Side effects and overdose of Lisinopril
Most often, patients who started therapy with this medicine, complained of cough, headache, nausea and diarrhea, general weakness, skin rash, too much pressure drop. Also, in rare cases, there occurred side effects associated with disorders of the various body systems.
Overdose of Lisinopril reduces blood pressure. Patients have dry mouth, urinary retention, and constipation. Also, the drug can cause irritability, anxiety, drowsiness. The treatment is to restore electrolyte balance, control and maintain pressure. Hemodialysis is also possible.