Drug Description

Lotrisone is an anti-skin infection cream containing two main substances: clotrimazole and betamethasone. It is used for the treatment of infections caused by fungus.
Lotrisone belongs to the steroids, which helps to reduce swelling and skin itching. The generic name of the Lotrisone is Clotrimazole and Betamethasone dipropionate which is well-known for its ability to regulate the functioning of certain processes leading to the skin infections.
Lotrisone cream was approved by FDA (1961) and became one of the most important medicines present in the basic health system.

Essential information

This cream is mainly used for the treatment of crotch itch, ringworm and athlete’s food. However, you should avoid abusing the cream.
According to the clinical researches, patients using Lotrisone cream experienced a significant relieve from skin infections compared with those treated with Clotrimazole cream.
Rashes caused by the use of diapers must not be treated with Lotrisone. You can see the effect in about 14 days. Therefore, you should take the drug during this time. If you note the improvements in 1-2 weeks, then you don’t have to consult your doctor.
You should strictly follow the doctor’s instructions or to the drug instructions to achieve maximum effect. If you suffer from any kind of allergies or taking any other drug, you should consult your doctor immediately. Avoid using this cream if you are allergic to the main active substance of the drug.
Tell your physician if you have a skin infection before purchasing the cream. Inform your doctor if you’re pregnant or planning the pregnancy. You shouldn’t use the cream during breastfeeding, as it is unknown whether this drug can get into the breast milk.


Lotrisone must not be applied on open wounds, especially in skin areas affected by sunburn and windburn. Actually, it must not be used on the irritated skin.
Read the drug instruction carefully to achieve the best effect from the drug.
Using the cream after its expiration is forbidden. The best way to use it is to take a thin layer of cream, and then rub it gently into the skin.
Never abuse the cream, as it may cause overdose. Avoid taking this medicine orally, as it can cause serious adverse effects. Ask the doctor about the proper ways of using this cream. Never use Lotrisone on the sunburned or tanned skin. Avoid applying this cream to the open wounds or cuts near the affected skin area.
If Lotrisone accidentally contacts the most sensitive areas like eyes, mouth, nostrils, anal or vaginal areas, rinse them properly at once.
Avoid wearing clothes right after the application of the cream, as you should leave the cream to dry. Apply the cream only to the dry feet, if you’re treating tinea pedis. Use the cream for a maximum of 14 days for the treatment of tinea cruris, and a month for the treatment of tinea pedis.

Skipping the dose/overdose

Try to apply the cream at the same time every day to avoid missing the dose. If you skipped the dose Lotrisone, apply it as soon as possible. If it’s already time for the next dosage, skip it and apply only the scheduled one. Never abuse the cream. In case of overdose, wipe the excesses of cream with a clean cotton wool.

Adverse effects

Considering the high chances of the cream getting absorbed through the skin, scientists warn about the risk of side effects in the adrenal gland. The most common adverse effects of Lotrisone are:

  • Depression,
  • Vertigo,
  • Increased weakness,
  • Muscle fatigue,
  • Vomiting,
  • Sudden weight loss,
  • Sickness.

According to the Food and Drug Administration, it is probable that patients may experience the other adverse effects as well.


Medicines (both in injections and in oral form) can reduce the effects of the antifungal cream. To ensure safety, patients using the cream must ask talk the doctor whether the cream can be used during the treatment with the other drug. This will help you to avoid the possibility of drug interaction.