Nexium belongs to the group of inhibitors of H+-K+-ATPase. It is available in two forms – in pill form (20 and 40 mg) and in the form of lyophilizate (40 mg, compressed weight) in order to prepare a solution, which is injected intravenously. The active ingredient in both forms is esomeprazole sodium.
Pharmacological action of pills and lyophilizate is identical. The drug reduces stomach acid secretion. The effect of the medicine comes rather quickly – within the hour. When the drug is taken regularly, the level of acid in the stomach is reduced by 90% during the week. Relief was observed in patients in 78% of cases. If the ulcer is uncomplicated, subsequent therapy is not needed. In more complex cases it is necessary to carry out the treatment on ulcer healing. However, it should be noted that in case of severe ulcer disease that is accompanied by bleeding, Nexium also effective.
Indications for use
Nexium is indicated for symptomatic treatment of gastroesophageal reflux disease, treatment of erosive reflux esophagitis, gastric ulcer and 12 duodenal ulcer, prevention of recurrence, during the healing of ulcer, etc. In turn, lyophilizate is prescribed in case of reflux disease, with the goal of healing and prevention of peptic ulcers and recurrent bleeding.
Now let’s describe the dosage, at first we’ll describe the dosage of pills. Children over 12 and adults are recommended to follow the following scheme. In the case of gastroesophageal reflux disease the drug is taken only once per day in amount of 40 mg. But you should take it as a whole. Support course, which can last long enough, implies taking 20 mg once a day.
As for stomach ulcers and 12 duodenal ulcer, you can by Nexium online to used in the combined therapy prescribed in a dose of 20 mg to be taken two times a day for weeks. In case of severe peptic ulcer bleeding, Nexium should be taken at a dose of 40 mg once a day throughout the month. Ulcer prevention involves the reception of the medicament in a daily dosage of 20 mg.
Lyophilizate is an alternative if you cannot use pills. It is intended for adults only. The maximum daily dose of 40 mg. It is injected intravenously. Unlike the oral variant, this form is characterized by a brief period of action. The advantage is the fact that there’s a faster action.
Contraindications include age under 12 years, incompatibility with products containing nelfinavir and atazanavir, high susceptibility of components of the drug. During the treatment of patients with renal and hepatic insufficiency you need to use Nexium very carefully. Nexium online instruction for use, in turn, notes that during pregnancy and lactation, a decision on the appointment of the drug should be made by a doctor as there is a risk for children.