Drug Description

Ponstel is the brand name of Mefenamic acid that falls within the group of nonsteroidal anti-inflammatory drugs. This drug inhibits both constitutive and inducible isoform of cyclooxygenase (COX) and impedes the formation of prostaglandins. The prostaglandins falls within the group of physiologically active lipids present in every tissue of human body. As this drug belong to the class of anthranilic acid derivatives, it is efficiently used for the treatment of minor to moderate pain. This drug was approved by Food and Drug Administration (1967) for sale in the American markets.


Ponstel is used mostly to alleviate pain during menstruation. Moreover, it can be used for the treatment of migraine caused by periods. Take the drug at least 24 hours before the beginning of headache that appears during the period.
Moreover, Ponstel is used for the treatment of pain caused by arthritis. As this medicine increases the risk of heart stroke or other life threatening conditions, it is not used commonly.


Ponstel is sold in different dosages. An average recommended dosage is 500 mg for the treatment of acute pain in adults and child older than 14.
The usual initial dose is 250mg.
The second dosage of Ponstel must be taken at least 6 hours after the initial dose.
You can take Ponstel with meal. The dosage of the drug for the treatment of patients with primary dysmenorrhea remains unchanged (this disease causes lower abdominal pain during periods).

Adverse Effects

Common adverse effects, such as vomiting, anxiety, head pain, depression and tremor may happen and stop after the end of menstruation. Seek medical assistance if you notice any of the following adverse effects.

  • Vision impairment
  • Vomiting blood
  • Blood in urine
  • Muscle fatigue
  • Hypertension
  • Skin rash

If you note any of the above-mentioned adverse effects during the treatment with Ponstel, you must stop the treatment and consult your doctor to avoid undesirable adverse effects. They may happen if you take the drug longer or less than necessary.

Drug safety

During the treatment with Ponstel, the person must not take any non-prescription antibiotics or anesthetics without informing his/her doctor, as it may cause the drug interaction. Please tell your physician if you’re taking antidepressants such as Fluoxetine or Paroxetine alongside with this drug.
Patients with asthma, liver dysfunction, blood disorders and digestive problems must be extremely cautious during the treatment with Ponstel.