Drug Description

Premarin is the brand name for estrogen medicine containing conjugated estrogen. Low estrogen may lead to hot flashes, vaginal burning and dryness. This condition usually happens during menopause. Premarin can replace estrogen, used by the patients for the treatment of various types of cancers.

How it acts?

Premarin relieves the symptoms of menopause such as hot flashes, vaginal dryness and irritation caused by the organism that produces less estrogen. This drug releases enough estrogen for prevention and treatment of the above-mentioned symptoms. These pills contain conjugated estrogen as the active component. The drug efficiently relieves the symptoms of menopause.


Premarin is used for the treatment of different health conditions, such as hot flashes, burning, vaginal dryness and irritation, prevention of osteoporosis during the menopause and replacement of estrogen in women suffering from the lack of natural estrogen. In some cases, Premarin is used for the treatment of cancer.


The maximum dosage of Premarin for serious symptoms is 0.3 mg a day. In case of ovarian failure, take 0.625mg a day. Always stick to the doctor’s prescription to achieve the maximum effect.
The drug overdose may cause vomiting, vaginal hemorrhage, nausea, etc. In this case, you should call emergency at one. Smoking may enhance the risk of blood clotting, stroke or infarction.
Premarin pills must be taken once a day, irrespective of the mealtime. The drugs must be swallowed whole with a glass of water. Take the pills at the same time every day to avoid missing the dose. Check with your physician at least once a year regarding your need for continuing the hormone replacement therapy.


Premarin must not be used by pregnant women and people suffering from cancer, vaginal hemorrhage, liver dysfunction, blood clots, cardiovascular diseases or kidney dysfunctions.
During the treatment, you must do regular blood tests for calcium, pregnancy, etc.
Despite the fact that Premarin is available over-the-counter, you should use it with great caution. The drug misuse (in rare cases) may increase the risk of uterine cancer.
Stop the treatment immediately in case of vaginal hemorrhage.
Premarin must be taken for 3 weeks and it takes a week for monitoring. You will require monthly mammograms, blood tests, etc. to make sure there are no health problems.

Adverse effects

The most widespread adverse effects caused by the use of this drug are:

  • Yeast infection
  • Nausea, vomiting, stomachache, bloating, upset stomach and flatulence
  • Head pain or migraine
  • Hair loss
  • Chest pain and tenderness
  • Depression, nervousness and mood swings
  • Leg cramps
  • Weight fluctuations
  • Hypertension
  • Skin rash and itch
  • Gallbladder disorder
  • Jaundice
  • Blood clots in the blood vessels
  • Weakness and vertigo
  • Uterine myoma