Prinivil is a drug that affects the vascular system and heart. The active ingredient of the drug, which is called similarly, refers to the pharmacological group of inhibitors of ACE.
The drug is used for treatment of hypertension of patients who require combination therapy. This drug gets positive feedback from the people who have carried out medical therapy.
Active ingredient is lisinopril.
Indications for use
Essential and renovascular hypertension, congestive heart failure (in combination with digitalis and/or diuretics).
Hypersensitivity, child’s age.
Use during pregnancy
ACE inhibitors cause fetal and neonatal morbidity and mortality. The application of Prinivil during pregnancy is not recommended, except of cases when other drugs are forbidden or they are ineffective. Prinivil penetrates the placenta.
There are no data on the penetration of Prinivil in human milk. However, it is not recommended to prescribe it to nursing mothers without a sufficiently serious reason.
Angioedema of the face, lips, extremities, tongue, throat, dizziness, headache, confusion, weakness, asthenia, cough, orthostatic effects (including hypotension), tachycardia, myocardial infarction, diarrhea disorders, hepatitis, jaundice, urticaria, oliguria, uremia, renal failure, impotence, etc.
Overdose is characterized by hypotension. The patient should lie on bed and have an infusion of saline. Transient hypotension is not an indication for discontinuation of the drug.
Special care is required when prescribing the drug to patients with bilateral renal artery stenosis or stenosis of artery only kidneys (it is possible to increase of urea and creatinine in the blood), patients with coronary artery disease or cerebrovascular disease, severe heart failure (it is possible to cause hypotension, myocardial infarction, stroke).
If patients have congestive heart failure, the resulting hypotension may lead to deterioration of renal function. During extensive surgery or during anaesthesia with agents causing hypotension, Prinivil can block the formation of angiotensin II, secondary to compensatory secretion of renin. Safety and efficacy of reception of Prinivil to children is not established.
In general, the choice of drugs affecting the cardiovascular system should be done by a doctor. Even in this case, there are possible errors – often patients have to test the effect of several drugs until they find the optimal treatment scheme. Therefore, it is impossible to describe Prinivil as mostly successful or ineffective medicine – its activity is evaluated only individually.