In the treatment of acne, the stable improvement comes after 12-24 weeks of using (depending on the severity of the problem). But you should continue treatment for at least 6 months.
To achieve the rejuvenating effect, the treatment must last no less than 24 weeks, but for the stable result, we recommend you to use it for at least 48 weeks. Then you can changer for the supporting mode: apply the cream 2 times a week for the next 6 months.

Where and how much retinoid cream can you use?

Face, avoiding the corners of your mouth and nostrils. Use the cream of reduced concentration with caution near the eyes. In case of normal tolerance, you can use the drug the same area in the eye area as for the whole face.
Neck area is exposed to the irritation, but in case of normal tolerance, you can use it there as well.
The outside of your palm, as the rejuvenating cream for hands and lightening of pigmentation.
Evenly apply the small amount of cream. Avoid putting two layers of cream on the same place. The amount of “average pea” is often enough for the whole face.

What to do in case of worsening after the use of Retin-A cream?

If you applied too much cream and have severe irritation, burning and itching, put any anti-burning cream with aloe vera, which can help to soothe the skin. Then take a break for 1-2 days until the visible normalization of skin condition. Then continue to use it once in two days, gradually returning to the schedule “every day before bed”.


  • increased sensitivity to the derivatives of vitamin А.
  • pregnancy (the drug can affect the fetus and cause violations). Stop taking tretinoin two months before the anticipated pregnancy.
  • breastfeeding.
  • children under the age of 12.
  • acute inflammatory skin irritations (apart from acne).
  • eczema.
  • wounds and burns.
  • skin epithelioma.
  • expressed rosacea.

Don’t expose your skin to sunlight! Apply the protective cream SPF 30 before going out (use SPF 50+ when the sun is active)
After taking a sunbath, you can start using the tretinoin cream no earlier than in 7 days.
Don’t use it in combination with vitamin А.

Isn’t it harmful to use tretinoin cream or gel for so long?

Tretinoin cream is known better than the other retinoids. There was the research of the effect of retinoids in the long term. However, no severe side effects were identified. While following all the recommendations, this drug is safe and very effective for the treatment of acne and skin rejuvenation. If you use the tretinoin cream Retin A externally, the effect on the whole body will be quite low. However, if you use the retinol derivatives in pills, there’s a long list of contraindications!