Serpina is a drug from the group of sympatholytics that have a hypotensive and sedative effect, increases the effects of analgesics and hypnotics.

Indications for use

Arterial hypertension; Hyperkinetic syndrome; Psychoses due to high blood pressure; Mental illness vascular etiology. Serpina is also sometimes used in the following cases: mild forms of heart failure with tachycardia (in combination with cardiac glycosides); Thyrotoxicosis (together with thyreostatics drugs, to reduce neurovegetative disorders and ischemia heart rate); Hypersympathicotonia; Persistent insomnia; Schizophrenia (in combination with antipsychotics); Alcoholic psychoses.

Drug contraindications

Congestive heart failure; Severe cardiovascular disease; Bradycardia; AV-blockade; Depression; Ulcerative colitis exacerbation; Exacerbation of gastric ulcer and 12 duodenal ulcer; kidneys Diseases with the violation of their functions; Bronchial asthma; Nephrosclerosis; Atherosclerosis of cerebral vessels; the period before carrying out electro-therapy; pregnancy and lactation; Concurrent use of monoamine oxidase inhibitors and 1 week after their withdrawal; Hypersensitivity to the drug.

Method of reception and dosage

Serpina should be taken inside after meal. The specific dose and duration of treatment are determined individually. In the early stages of hypertension you should be prescribed 0.05-0.1 mg 2-3 times a day. Further, if necessary (but subject to good tolerability), the dose is gradually increased. Maximum daily dose is 1 mg. If within 10-14 days, the hypotensive effect is not achieved, the medication should be overturned. After reaching the effect, the daily dose should be gradually reduced: first, up to 0.5 mg, then up to 0.2 mg and then to 0.1 mg. You should be prescribed the minimum effective dose for maintenance therapy. Treatment is held in courses of 2-3 month up to 4 times a year. In case of neuroses Reserpine is taken in a dose of from 0.25 mg 2-3 times a day to 0.5 mg 3-4 times a day. In case of mental illness on the first day you should be prescribed 0,25-2 mg, then, depending on the clinical situation, the daily dose may be increased to 10-15 mg. the maximum dose for adults: single – 2 mg daily to 10 mg. Children depending on age and indications are prescribed a daily dose  of 0.1-0.4 mg in 2-4 intakes.

Side effects

From the digestive system: abdominal pain, nausea, diarrhea, vomiting, ulcerate the mucosa of the gastrointestinal tract; in the long admission at high doses – liver; urinary system: frequent urination or urinary retention; cardiovascular system: bradycardia; if the drug is taken in high doses – there may be symptoms of angina pectoris;  central and peripheral nervous system: dryness and swelling of the mucous membranes, fatigue, weakness, anxiety, dizziness, insomnia or drowsiness, depression; if the drug is taken in high doses, there may be nightmares, Parkinson’s disease; Dermatological reactions: pruritus, herpes; other: nasal congestion, hyperemia of the mucous membranes of the eyes, shortness of breath, weight gain, decrease of potency and libido.

Special instructions

Due to low efficacy and numerous side effects sympatholytics relate to tools of the second row in hypertension and psychoses. During treatment you should monitor blood pressure.

Drug interactions

Beta-blockers: there is a mutual enhancement of the pharmacological effects; Adrenergic and sympathomimetic: it is noted the mutual reduction activity; Antihypertensive agents: the antihypertensive effect is potentiated; Bromocriptine: the drug decreases its effect on prolactin levels (there should be a correction of dose); Alcohol and means, depressing the central nervous system: increased depressive effects; Nonsteroidal anti-inflammatory drugs (especially indomethacin): reduced antihypertensive effect; Anticholinergics: decreased influence on gastric secretion; Means for causing extrapyramidal disorder: increased disorders; Levodopa: reduced effect (requiring higher dosages); Quinidine, cardiac glycosides: develops effect
of pro-arrhythmia; Furazolidone, procarbazine, and monoamine oxidase inhibitors including selegiline: there is a risk of sudden hypertension and hyperpyrexia.