Sinequan is a drug from the group of tricyclic antidepressants.

Sinequan is derived from dibenzoxepin, it is an antidepressant of tricyclic structure. The drug weakens adrenergic transmission in the synapses of the central nervous system and blocks the reuptake of nor-epinephrine It has a sedative, antidepressant, anxiolytic and anti-ulcer action. The drug has antiserotonin, interscholastic and antihistamine effects as well as antispasmodic activity, muscle relaxant, anticoagulation and mild peripheral vasodilating effects. Medicine helps relieve depression, apathy, anxiety and internal tension, improves mood. It is effective in case of vegetative disorders of neurotic origin. A moderate antidepressant effect (a distinct effect on mood) is noted in 10-14 days after you start taking the drug. Persistent antidepressant effect occurs within 2-3 weeks of regular intake of capsules.

Indications for use

Psycho-neurotic disorders, accompanied by anxiety and/or depression; sleep disorders, anxiety and depression in neurosis, organic diseases of the central nervous system, and alcohol abuse; psychotic depression (including reactive and involutional depressive phase of manic-depressive psychosis). In general therapeutic practice, Sinequan is used to treat the following diseases: dumping syndrome; chronic idiopathic urticaria; itching; premenstrual syndrome; peptic ulcer of 12 duodenal ulcer; chronic pain in patients who suffer from cancer.

Drug Contraindications

Absolute: age to 12 years; atrioventricular block of the 3rd degree, blockade of the left bundle branch block; angle-closure glaucoma; benign of prostatic hyperplasia or conditions associated with urinary retention; severe dysfunction of the hematopoietic system, liver and kidneys; acute myocardial infarction; pregnancy and lactation; hypersensitivity to the drug.

It should be used with caution in cases of severe cardiovascular disease; malnourished patients; elderly age.

Special instructions

During treatment alcohol consumption is prohibited. Do not discontinue therapy abruptly, because there may be evolution of the withdrawal syndrome. You should stop taking the drug gradually.


In case of overdose it may develop the following side effects: dilated pupils, drowsiness, dry mouth, hallucinations, nausea, blurred vision, arrhythmias, tachycardia, severe hypotension, respiratory depression, stupor, typical for intoxication with tricyclic antidepressants, ECG changes (particularly in QRS), muscle rigidity, convulsions, coma. In this case you should perform gastric lavage, mechanical ventilation, correction of the function of the cardiovascular system. If necessary, you should take physostigmine. Hemodialysis is ineffective.