Drug Description

Tofranil is an antidepressant, also available in the generic version known as Imipramine. The drug belongs to the group of tricyclic antidepressants of the dibenzazepine group. The drug acts by inhibiting the reuptake of serotonin, norepinephrine, and histamine H1 receptors. These characteristics allow using this drug for the treatment of various diseases.

Drug information

Tofranil is prescribed for the treatment of various diseases (chronic pain, withdrawal symptoms from drug addiction, depression, OCD, panic attacks and attention deficit hyperactivity disorder is some patients).
If depression is not diagnosed properly, and the medicine is used without knowledge of the same, the symptoms of disease may become worse, especially in patients with manic depression.
Tofranil must not be taken by pregnant or breastfeeding women, patients with a history of drug or alcohol addiction, glaucoma, thyroid problems, patients with severe mental diseases and those with suicidal thoughts.


The common dosagees of Tofranil are 10 mg, 25 mg, and 50 mg. The drug effects varies from person to person. The common half-life of this drug is 24 hours. However, its effects may last much longer.
Tofranil must be taken strictly according to the doctor’s prescription. Never change the dosage or the duration of treatment. Read the drug instructions carefully to make sure that you’re aware of any essential information about the use.
Don’t stop the treatment with Tofranil without medical help. Reduce the dosage gradually to prevent the withdrawal syndrome. Avoid operating dangerous machinery after taking the drug. It can be taken irrespective of the mealtime. Consult your doctor before changing the dose.

Adverse effects

Potential adverse effects of Tofranil are:

  • stomach diseases,
  • photosensitivity,
  • bad taste in the mouth,
  • reduced libido,
  • rash,
  • difficulty urinating.

If you have more serious adverse effects, consult your doctor at once. Overdose can be very dangerous if not treated in time.


People must be aware of potential drug interactions and inform the doctor about any drugs you’re taking. Avoid combining Tofranil with other antidepressants, such as MAO inhibitors, selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), as it enhances the risk of adverse effects.
The use of anticoagulants, glaucoma and thyroid drugs, stimulants and antihistamines can reduce the effect of Imipramine.
Avoid smoking, as it reduces the effectiveness of the antidepressant.