Drug Description

Zestoretic is a combination drug containing hydrochlorothiazide and lisinopril (the latter is the generic name of this drug). Lisinopril is a long-acting ACE inhibitor able to can transform enzymes. It looks like white crystalline powder, soluble in water and insoluble in ethanol. Hydrochlorothiazide is a white crystalline powder, almost insoluble in water and easily soluble in sodium hydroxide solution.


Zestoretic is mostly used for the treatment of hypertension. Both active substance of this drug work together to reduce the blood pressure. Lisinopril falls within the group of drugs called angiontensin inhibitors and acts to dilate the blood vessels. Hydrochlorothiazide belongs to the group of medicines called diuretics and helps the body to get rid of water and salt in the urine.


Zestoretic oral pills are sold in three different dosages with different contents of Lisinopril and Hydrochlorothiazide. The dosage combinations are 10/12.5 mg, 20/12.5 mg, and 20/25 mg of Lisinopril and Hydrochlorothiazide respectively. The dose is titrated depending on the severity of the diseases and the patient’s reaction to the drug.
One must take Zestoretic strictly according to the prescription. Read the drug instruction carefully and stick to it. Take this medicine orally once a day in the morning with a full glass of water, irrespective of the mealtime. If the medicines case frequent urination, you should take it 4 hours before sleep to avoid waking up at night. The dosage also depends on the patient’s age and reaction to the drug.

Safety information

You must not stop taking Zestoretic even if you feel better. Inform your physician about all the blood pressure ratings to avoid dangerous side effects.
Avoid taking potassium or salt substitutes during the treatment with Zestoretic. You must not consume alcohol, as it can increase the risk of side effects. If you do exercises, always stay hydrated and avoid overheating. Don’t change the dosage without the doctor’s approval, as it may cause undesirable and even life-threatening consequences.
Pregnant women must avoid using Zestoretic, as it may cause fetal toxicity and even be fatal. If you get pregnant during the treatment, consult your doctor immediately. Lactating is also forbidden, as the medicine can affect the newborn through the breast milk.
To ensure safety of treatment, tell the doctor if you have any of the following diseases: allergies, cardiovascular disease, glaucoma, diabetes, liver or kidney dysfunction, penicillin intolerance and recent organ transplantation.

Adverse effects

Seek immediate medical assistance if you note such symptoms of allergic reactions as stomachache, breathing problems, face swelling or sore throat. Consult your doctor if you suffer from fever, pain in the eye, anxiety, sleeplessness, vision impairment, jaundice, urination problems, sickness, constipation, cramps in the legs, extreme thirst, urination frequency, head pain, vomiting and confusion.