Zestril is the drug that affect ‘ cardiovascular system. The drug active substance with the same name, belongs to the group of APF inhibitors. This drug is similar to Dirotone. In other words, Zestril impedes the transformation of Angiotensin I into Angiotensin II, which results in the pressure drop in the major vessels (mostly in the arteries). On the contrary, the blood flow to the capillaries is increasing. You can note the maximum reduction of blood pressure in about 6 hours after the drug intake. Zestril improves the condition of heart muscle. In the long-term use, hypertrophic myocardium returns to its natural state. Besides, this drug can reduce the excretion of protein with urine (due to the improved state of filtering tissue in kidneys).

Indications for use

  • Hypertonic diseases
  • Chronic heart failure
  • Early stages of treatment of myocardial infarction (to maintain the functioning of left ventricle)
  • Diabetic nephropathy

Zestril is available in pills with different concentrations of active substance. You should start the treatment with low dosages, which must be then corrected depending on the effectiveness. According to the instruction, the patients using diuretics must withdraw them a few days before starting to use this drug. Otherwise, it can cause significant reduction of blood pressure. Therefore, the patient must be under the medical supervision 6 hours after the intake of Zestril to correct (if necessary) the patient’s condition, maintaining the normal level of blood pressure).
The patients with kidney dysfunction and the old patients require the correction of dosage, as lisipronil disrupts the metabolism of lisinopril. Actually, the indications to the use of this drug are outlined in the instruction.
You can take this drug irrespective of the mealtime.


  • Angioedema (as a reaction to APF inhibitors)
  • Inherited Quincke’s disease
  • Other types of drug intolerance
  • Underaged patients
  • Renal vascular diseases
  • Kidney failure
  • Ischemic heart diseases
  • Coronary artery diseases
  • Auto-immune disease
  • Some disorders of water and salt balance

Side effects and overdose

The most frequent side effects are cough, headache, sickness and diarrhea, fatigue, skin rash, too low blood pressure. In rare cases, the patients suffer from the side effects related to the disruption of different body systems.
Overdose can cause the expressed reduction of blood pressure, dry mouth, urinary retention and constipations, irritability, anxiety and drowsiness. The treatment includes the restoration of water and salt balance and control and maintenance of blood pressure. Haemodialysis is also possible.